|
KMID : 1134820170460091027
|
|
Journal of the Korean Society of Food Science and Nutrition
2017 Volume.46 No. 9 p.1027 ~ p.1034
|
|
|
Immunomodulatory Effects of an Extract from Pinus koraiensis Cone Peel in LP-BM5 Murine Leukemia Viruses-Induced Murine Acquired Immune Deficiency Syndrome
|
|
Kim Seong-Pil
Kwon Han-Al
Ha Ye-Jin
Heo Seok-Hyun
Lee Jeong-Min
|
|
|
Abstract
|
|
|
|
The immune system is a complex process within the body that protects against disease. Recently, many studies have attempted to discover immunomodulative compounds from natural sources. Pinus koraiensis (PK) cone shell is a by-product of PK. One of the major compounds of PK cone shell is dehydroabietic acid, which has bioactivity, including antiulcer and anti-inflammatory activities. Therefore, this study was performed to examine the immunomodulative effects of PK cone shell. The immunomodulatory effects of PK cone shell extracted with 20% ethanol (EtOH) in vivo were examined initially by measuring the natural killer (NK) cell activity, phagocytic activity, Th1/Th2 cytokines release, serum immunoglobulin, and T/B cell proliferation. The NK cell activity and phagocytic activity were increased significantly by a treatment with a 20% EtOH extract of PK cone shell. Th1 type cytokine and T cell proliferation increased and Th2 type cytokine, B cell proliferation and serum immunoglobulin A, G, and E decreased after a treatment with PK cone shell extract. The 20% EtOH extract of the PK cone shell normalized the unbalanced production of Th1/Th2 type cytokine. This suggests that a 20% EtOH extract of PK cone shell has great potential as a health food.
|
|
|
KEYWORD
|
|
|
pine cone, Pinus koraiensis, immunomodulatory effect, cytokines, immune deficiency syndrome
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|